A eukaryotic-like 3′ untranslated region in Salmonella enterica hilD mRNA

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A eukaryotic-like 3′ untranslated region in Salmonella enterica hilD mRNA

Long 3' untranslated regions (3'UTRs) are common in eukaryotic mRNAs. In contrast, long 3'UTRs are rare in bacteria, and have not been characterized in detail. We describe a 3'UTR of 310 nucleotides in hilD mRNA, a transcript that encodes a transcriptional activator of Salmonella enterica pathogenicity island 1 (SPI-1). Deletion of the hilD 3'UTR increases the hilD mRNA level, suggesting that t...

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ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1) is an inflammatory-induced gene. We have previously reported that ADAMTS1 was strongly but transiently expressed in the infarcted heart. In this study, we investigated whether a 3'-untranslated region (UTR) affects the mRNA stability of this gene. When stimulated with tissue necrosis factor (TNF)-alpha, the expression le...

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Roles of hilC and hilD in regulation of hilA expression in Salmonella enterica serovar Typhimurium.

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2014

ISSN: 1362-4962,0305-1048

DOI: 10.1093/nar/gku222